Preferred Label : Copper Cu 64 NODAGA-TTX-MC138;
NCIt synonyms : 64Cu-NODAGA-TTX-MC138; Cu-64 labeled TTX-MC138; TTX-MC138-NODAGA-Cu64;
NCIt definition : A radioconjugate comprised of the microRNA-10b (miR-10b)-inhibitor TTX-MC138, which
consists of an anti-miR10b antagomir conjugated to ultrasmall iron oxide nanoparticles,
chelated with 1,4,7-triazacyclononane,1-glutaric acid-4,7 acetic acid (NODAGA) and
radiolabeled with the radiotracer copper Cu 64, that may be used as an imaging agent
for miR-10b-overexpressing tumor cells upon positron emission tomography (PET)-magnetic
resonance imaging (PET-MRI). Upon administration of copper Cu 64 NODAGA-TTX-MC138,
the TTX-MC138 moiety targets and binds to miR-10b inside tumor cells. This allows
for visualization of miR-10b-overexpressing tumor cells upon imaging with PET-MRI.
miR-10b, a mRNA that is highly expressed in a variety of metastatic tumor cells, plays
a key role in tumor cell migration, invasion and metastasis.;
NCI Metathesaurus CUI : CL1907391;
Origin ID : C200369;
concept_is_in_subset
- has_target
