Preferred Label : Irinotecan Liposome HR070803;
NCIt synonyms : Liposomal Irinotecan HR070803;
NCIt definition : A liposomal formulation of the semisynthetic camptothecin analogue irinotecan, with
potential antineoplastic activity. Upon administration of irinotecan liposome HR070803,
irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes during the
S phase of the cell cycle, inhibiting religation of topoisomerase I-mediated single-strand
DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered
by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient
drug delivery into the cytosol from the endosome compartment of the cell.;
Molecule name : HR-070803; HR 070803;
NCI Metathesaurus CUI : CL1907146;
Origin ID : C200345;
concept_is_in_subset
