Preferred Label : Mutated Human Nerve Growth Factor CHF6467;
NCIt synonyms : Mutated rhNGF CHF6467; Mutated hNGF CHF6467; hNGF P61S R100E;
NCIt related terms : CHF-6467;
NCIt definition : A topical preparation containing the R100E mutated form of the human recombinant nerve
growth factor (NGF), with potential neuroprotective, neurotrophic and wound healing
activities and with reduced pain induction activity. Upon topical administration,
mutated rhNGF CHF6467, by mimicking the natural-occuring neurotrophin, binds with
high affinity to the tropomyosin receptor kinase A (TrkA) NGF receptor located on
peripheral and central neurons and activates protein kinase B/mammalian target of
rapamycin (mTOR) pathway signaling. This induces NGFs pleiotropic effects and may
prevent prevent loss of nerve-endings and visual damage, and may promote sensory skin
innervation, neoangiogenesis and skin wound healing. The R100 mutation abolishes the
hyperalgesic effect that is usually associated with NGF without affecting most neurological
functions.;
UNII : 4DL2E33KNV;
Molecule name : CHF 6467; CHF-6467;
NCI Metathesaurus CUI : CL1907116;
Origin ID : C200308;
UMLS CUI : C5854514;
Semantic type(s)
- concept_is_in_subset
