Preferred Label : Anti-nectin-4 Antibody-drug Conjugate 9MW2821;
NCIt synonyms : Anti-nectin-4/MMAE ADC 9MW2821; Anti-nectin-4 ADC 9MW2821; ADC 9MW2821;
NCIt definition : An antibody drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against the cell surface adhesion molecule and tumor-associated antigen (TAA) nectin-4
(PVRL4), site-specifically conjugated, via a linker, to the cytotoxic agent monomethyl
auristatin E (MMAE), with potential antineoplastic activity. Upon administration of
the anti-nectin-4 ADC 9MW2821, the anti-nectin-4 antibody targets and binds to nectin-4
expressed on tumor cells. Upon binding and internalization, MMAE binds to tubulin
and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis
in nectin-4-expressing tumor cells. Nectin-4, a TAA belonging to the nectin family,
is overexpressed in a variety of cancers, but has a restricted distribution in normal
tissue.;
Molecule name : 9MW 2821; 9MW-2821;
NCI Metathesaurus CUI : CL1907102;
Origin ID : C200283;
concept_is_in_subset
- has_target
