" /> Bulumtatug Fuvedotin - CISMeF





Preferred Label : Bulumtatug Fuvedotin;

NCIt synonyms : Anti-nectin-4/MMAE ADC 9MW2821; Anti-nectin-4 ADC 9MW2821; ADC 9MW2821; Anti-nectin-4 Antibody-drug Conjugate 9MW2821;

NCIt definition : An antibody drug conjugate (ADC) composed of bulumtatug, a humanized monoclonal antibody directed against the cell surface adhesion molecule and tumor-associated antigen (TAA) nectin-4 (PVRL4), site-specifically conjugated, via a linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of bulumtatug fuvedotin, the anti-nectin-4 antibody targets and binds to nectin-4 expressed on tumor cells. Upon binding and internalization, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4-expressing tumor cells. Nectin-4, a TAA belonging to the nectin family, is overexpressed in a variety of cancers, but has a restricted distribution in normal tissue.;

UNII : 3L9KU8WUU3;

CAS number : 2862919-82-0;

Molecule name : 9MW 2821; 9MW-2821;

NCI Metathesaurus CUI : CL1907102;

Details


You can consult :


Nous contacter.
09/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.