Preferred Label : KRAS G12C Inhibitor GEC255;
NCIt definition : An orally bioavailable small molecule inhibitor of the oncogenic KRAS substitution
mutation G12C, with potential antineoplastic activity. Upon oral administration, KRAS
G12C inhibitor GEC255 selectively targets the KRAS G12C mutant and inhibits KRAS G12C-mediated
signaling. This may halt proliferation and metastasis in susceptible tumor cells.
KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling,
division and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell proliferation, invasion, and metastasis.;
Molecule name : GEC 255; GEC-255;
NCI Metathesaurus CUI : CL1907082;
Origin ID : C200260;
concept_is_in_subset
- has_target
