Preferred Label : Recombinant Newcastle Disease Virus-encoding Interleukin-12 V938;
NCIt synonyms : Recombinant NDV-encoding IL-12 V938;
NCIt definition : An oncolytic, replication-competent strain of the avian paramyxovirus Newcastle disease
virus (NDV) that has been engineered to encode human pro-inflammatory cytokine interleukin-12
(IL-12), with potential antineoplastic and immunostimulating activities. Upon administration,
recombinant NDV-encoding IL-12 V938 specifically infects and replicates in cancer
cells. This may result in a direct cytotoxic effect involving the lysis of tumor cells
via apoptotic mechanisms and may eventually lead to an inhibition of cancer cell proliferation.
The production and secretion of IL-12 may potentiate and strengthen the anti-tumor
immune response and activates the immune system by promoting the activation of natural
killer cells (NK cells), inducing secretion of interferon-gamma (IFN-g) and promoting
cytotoxic T-lymphocyte (CTL) responses against tumor cells.;
Molecule name : V-938; V 938;
NCI Metathesaurus CUI : CL1907070;
Origin ID : C200246;
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