Acetylcholinesterase Collagenic Tail Peptide

Preferred Label : Acetylcholinesterase Collagenic Tail Peptide;

NCIt synonyms : COLQ; Acetylcholinesterase-Associated Collagen; AChE Q Subunit;

NCIt definition : Acetylcholinesterase collagenic tail peptide (455 aa, 48 kDa) is encoded by the human COLQ gene. This protein plays a role in localizing asymmetric acetylcholinesterase to the endplate of the neuromuscular junction.;

NCIt note : Acetylcholinesterase collagenic tail peptide is a collagen-like protein that forms a triple helix in the synaptic basal lamina of the endplate of the neuromuscular junction; each helix contains a proline-rich attachment domain (PRAD), which associates with acetylcholinesterase tetramers to anchor the catalytic subunits to the endplate.;

Details

Origin ID

C200237;

UMLS CUI

C1431449;

OMIM relation
- Collagenic tail of endplate acetylcholinesterase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- COLQ protein, human [MeSH Supplementary Concept]
- COLQ protein, human [MeSH concept]
gene_encodes_gene_product
- COLQ Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Basal Lamina [NCIt concept]
- Synapse [NCIt concept]
gene_product_has_biochemical_function
- Scaffolding Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Catabolic Process [NCIt concept]
- Heparin Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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