Preferred Label : Anti-nectin-4 Antibody-drug Conjugate SHR-A2102;
NCIt synonyms : ADC SHR-A2102; Anti-nectin-4 ADC SHR-A2102;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal
antibody directed against the tumor-associated antigen (TAA) nectin-4 (PVRL4) conjugated,
via a cleavable linker, to a topoisomerase-1 inhibitor, with potential antineoplastic
activity. Upon intravenous administration, the monoclonal antibody moiety of anti-nectin-4
ADC SHR-A2102 targets and binds to nectin-4 expressed on tumor cells. Upon binding,
internalization and linker cleavage, topoisomerase-1 inhibitor is released and inhibits
DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in
cell cycle arrest and apoptosis in tumor cells expressing nectin-4. Nectin-4 is overexpressed
in a variety of cancers, but has a restricted distribution in normal tissue.;
Molecule name : SHR A2102; SHR-A2102;
NCI Metathesaurus CUI : CL1907042;
Origin ID : C200198;
UMLS CUI : C5854493;
Semantic type(s)
- concept_is_in_subset
- has_target
