Preferred Label : Anti-CD44v9 Antibody-drug Conjugate AMT-116;
NCIt synonyms : ADC AMT-116; Anti-CD44v9 ADC AMT-116;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody directed against the tumor-associated antigen (TAA) CD44 variant
9 (CD44v9), linked to the topoisomerase I inhibitor (TOP1i) and belotecan derivative
KL610023 via a hydrolysable linker, with potential antineoplastic activity. Upon intravenous
administration of anti-CD44v9 ADC AMT-116, the monoclonal antibody moiety targets
and binds to CD44v9 expressed on tumor cells. Upon binding and internalization, KL610023
is released. KL610023 targets and binds to DNA topoisomerase I, thereby inhibiting
DNA replication and killing the CD44v9-expressing cancer cells. CD44v9, a splicing
variant of CD44 overexpressed in numerous cancer cell types, is associated with tumorigenicity
and cancer treatment resistance.;
Molecule name : AMT 116; AMT-116;
NCI Metathesaurus CUI : CL1906985;
Origin ID : C200143;
UMLS CUI : C5854480;
Semantic type(s)
- concept_is_in_subset
