Preferred Label : TGF-beta-15 Peptide Vaccine;
NCIt synonyms : TGF-beta-15 Peptide-Montanide Vaccine; TGFb-15 Peptide Vaccine;
NCIt definition : A vaccine composed of the transforming growth factor-beta (TGF-beta; TGFb)-derived
peptide TGF-beta-15 combined with the immunoadjuvant montanide ISA-51, with potential
immunomodulating and antineoplastic activities. Upon administration, TGF-beta-15 peptide
vaccine may activate TGF-beta-specific CD4 and CD8 T-cells and stimulate the host
immune system to mount a cytotoxic T-lymphocyte (CTL) response against TGF-beta-expressing
immunosuppressive cells in the tumor microenvironment (TME), including tumor-associated
macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), tolerogenic dendritic
cells (DCs), regulatory T-cells (Tregs), and cancer-associated fibroblasts (CAFs).
This may restore the anti-tumor immune response. TGF-beta, dysregulated in many types
of cancer, plays a key role in immunosuppression in the TME, enhances tumor cell proliferation,
and promotes cancer progression.;
NCI Metathesaurus CUI : CL1906951;
Origin ID : C200117;
UMLS CUI : C5856110;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
