Monoclonal Antibody J591

Preferred Label : Monoclonal Antibody J591;

NCIt synonyms : J591; J591 Monoclonal Antibody;

NCIt definition : Monoclonal recombinant antibody J591 (mAb HuJ591) recognizes the extracellular domain of prostate specific membrane antigen (PSMA), a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells of numerous solid tumor malignancies. Early results of clinical Phase I and II studies indicate that mAb HuJ591 represents targeted therapy to PSMA and has therapeutic potential in disseminated prostate cancer and other urological and solid tumor malignancies and did not result in a host immune response to the antibody. (NCI);

Details

Origin ID

C2001;

UMLS CUI

C1312991;

Currated CISMeF NLP mapping
- J591 monoclonal antibody [MeSH concept]
- J591 monoclonal antibody [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- J591 monoclonal antibody [MeSH concept]
- J591 monoclonal antibody [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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