Preferred Label : Trovostobart;
NCIt synonyms : Anti-VISTA Monoclonal Antibody KVA12123;
NCIt definition : An engineered, human immunoglobulin (Ig) G1 monoclonal antibody directed against the
negative immune checkpoint regulatory protein V-domain Ig suppressor of T-cell activation
(VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential negative immune checkpoint
regulatory and antineoplastic activities. Upon administration, trovostobart targets
and binds to VISTA on myeloid cells and T-cells within the tumor microenvironment
(TME). This inhibits VISTA-mediated signaling, decreases the presence of monocytic
myeloid-derived suppressor cells (MDSCs), increases the presence of natural killer
cells (NKs), activates dendritic cells (DCs) and abrogates VISTA-induced suppression
of T-lymphocyte immune responses. This enhances cytotoxic T-cell infiltration, proliferation
and activation within the TME, increases cytokine production by T-cells, and inhibits
tumor cell growth. VISTA, a negative checkpoint molecule of immune activation, is
highly expressed on myeloid cells, T-cells and in several tumor types. It plays a
key role in the suppression of T-cell function.;
UNII : ATY7DC4MSF;
CAS number : 3006784-09-1;
Molecule name : KVA-12123; KVA 12123; KVA12.1;
NCI Metathesaurus CUI : CL1906545;
Origin ID : C199642;
UMLS CUI : C5854447;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
