Preferred Label : Protein-engineered Interleukin-12 XTX301;
NCIt synonyms : Protein-engineered IL-12 XTX301; Tumor-activated Engineered Interleukin 12 XTX301;
NCIt definition : An engineered form of the human cytokine interleukin-12 (IL-12) in which the IL-12
is conjugated, via a tumor protease-cleavable linker, to a protein-engineered masking
domain that prevents the binding of IL-12 to its receptors while in circulation and
a half-life extension domain that prolongs circulating half-life, with potential immunomodulatory
and antineoplastic activities. Upon administration of protein-engineered IL-12 XTX301,
IL-12 is bound to the masking domain and pharmacologically inactive. Upon proteolytic
cleavage by matrix metalloproteinases (MMPs) in the tumor microenvironment (TME),
active IL-12 is released. IL-12 activates the immune system by promoting the secretion
of interferon-gamma (IFN-g) and activating CD8 T-cells, CD4 T-cells and natural
killer cells (NKs). The activation and expansion of these immune cells mediate cytolytic
immune responses against tumor cells, thereby killing tumor cells and inhibiting tumor
cell proliferation. The selective activation in the TME enhances the IL-12-mediated
cytolytic responses against tumor cells while sparing the unwanted effects of systemic,
peripheral immune activation.;
Molecule name : XTX-301; XTX 301;
NCI Metathesaurus CUI : CL1906529;
Origin ID : C199629;
concept_is_in_subset
