Preferred Label : Allogeneic Anti-CD33 CAR-NK Cells QN-023a;
NCIt synonyms : Allogeneic iPSC-derived NK Cells QN-023a; Allogeneic CD33-CAR iNKs QN-023a;
NCIt definition : A preparation of off-the-shelf (OTS), allogeneic natural killer (NK) cells, derived
from genetically engineered human induced pluripotent stem cells (iPSCs), that are
genetically engineered to express a chimeric antigen receptor (CAR) specific for the
tumor-associated antigen (TAA) cluster of differentiation 33 (CD33), and containing
a high-affinity, non-cleavable CD16 (hnCD16) to enhance antibody-dependent cell-mediated
cytotoxicity (ADCC), an interleukin-15 (IL-15) molecule to increase the persistence
of allogeneic cells in vivo, and a CD38 knockout to avoid depletion of CAR-NK cells,
with potential immunomodulating and antineoplastic activities. Upon administration,
the allogeneic anti-CD33 CAR-NK cells QN-023a recognize, bind to and induce selective
cytotoxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent
hematopoietic stem cells and on myeloid leukemia cells.;
Molecule name : QN 023a; QN-023a;
NCI Metathesaurus CUI : CL1906520;
Origin ID : C199622;
UMLS CUI : C5854439;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
