Preferred Label : Topical Gel HT-001;
NCIt definition : A topical gel formulation, with potential immunomodulatory activity that can potentially
be used for treatment of epidermal growth factor receptor (EGFR) inhibitor (EGFRI)-induced
skin toxicity. Upon application of the topical gel HT-001 to the affected area(s)
of the skin, scalp and nails, HT-001 is able to inhibit the recruitment and activation
of immune cells and inhibit the expression of inflammatory mediators that are induced
by EGFR signaling blockade resulting from EGFRI cancer therapy. This may prevent or
reduce inflammation, reduce substance P and reduce neutrophil activity, thereby preventing
and/or clearing the rash and the associated itching and/or hair loss induced by EGFRI
therapy. EGFR signaling is critical to maintain normal, healthy skin homeostasis.
EGFR inhibition results in high influx of inflammatory cells and production of pro-inflammatory
cytokines in the skin. EGFR signaling blockade increases C-C motif chemokine ligand
2 (CCL2) and 5 (CCL5) expression.;
Molecule name : HT-001; HT 001;
NCI Metathesaurus CUI : CL1906499;
Origin ID : C199597;
UMLS CUI : C5849087;
Semantic type(s)
- concept_is_in_subset
