Preferred Label : Anti-FAP Antibody-drug Conjugate OMTX705;
NCIt synonyms : Anti-FAP ADC OMTX705;
NCIt definition : An antibody-drug conjugate (ADC) composed of OMTX005, a humanized monoclonal antibody
directed against fibroblast activation protein (FAP), conjugated to the cytotoxic
tubulysin TAM470, with potential antineoplastic activity. Upon administration of anti-FAP
ADC OMTX705, the anti-FAP monoclonal antibody moiety targets and binds to FAP expressed
on cancer-associated fibroblasts (CAFs) in the tumor stroma. Upon binding, internalization
and linker cleavage, the cytotoxic moiety is released, which binds to tubulin and
inhibits microtubule polymerization. This results in G2/M phase arrest and the apoptosis
of FAP-expressing CAFs. FAP, a membrane-bound serine protease overexpressed on CAFs,
is minimally expressed on normal, healthy cells.;
Molecule name : OMTX-705; OMTX 705;
NCI Metathesaurus CUI : CL1906935;
Origin ID : C199584;
concept_is_in_subset
- has_target
