Preferred Label : Allogeneic Gene-modified Gamma Delta T-cells;
NCIt synonyms : Allogeneic Genetically Modified Gamma-delta T Cells;
NCIt definition : A preparation of genetically modified allogeneic gamma delta T-lymphocytes, with potential
immunomodulating and antineoplastic activities. Upon administration, the allogeneic
gene-modified gamma delta T-cells secrete interferon-gamma (IFN-g) and exert direct
killing of tumor cells. In addition, these cells activate the immune system to exert
a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes
play a key role in the activation of the immune system and do not require major histocompatibility
complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The genetic
modification of the allogeneic gene-modified gamma delta T-cells may confer resistance
to alkylating chemotherapeutic agents including temozolomide and allow the use of
the gamma delta T-cells as an adjunct to these agents.;
NCI Metathesaurus CUI : CL1906852;
Origin ID : C199489;
UMLS CUI : C5855623;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
