Preferred Label : Allogeneic Skin-derived ABCB5-positive MSCs allo-APZ2-OTS;
NCIt synonyms : Allogeneic Skin-derived ABCB5-positive Mesenchymal Stem Cells allo-APZ2-OTS;
NCIt definition : A preparation of off-the-shelf (OTS) allogeneic human dermal ex-vivo expanded mesenchymal
stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter,
subfamily B, member 5 (ABCB5) that can potentially be used in the treatment of various
skin-related and systemic inflammatory and degenerative conditions, such as recessive
dystrophic epidermolysis bullosa (RDEB). Upon administration of the allo-APZ2-OTS,
the MSCs are able to differentiate into several lineages, provide immunomodulatory
activity, interact with various immune cells, such as macrophages, neutrophils and
regulatory T-cells (Tregs), and are able to secrete various anti-inflammatory mediators
and pro-angiogenic molecules. Altogether, allo-APZ2-OTS may contribute to inflammation
control and tissue repair.;
Molecule name : allo-APZ2-OTS;
NCI Metathesaurus CUI : CL1906835;
Origin ID : C199466;
UMLS CUI : C5854421;
Semantic type(s)
- Cell [UMLS semantic type]
concept_is_in_subset