NCIt definition : A T-cell engaging, human, bispecific, immunoglobulin G1 (IgG1) monoclonal antibody
directed against the tumor-associated antigen (TAA) human B-cell maturation antigen
(BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and CD3 antigen
found on T-lymphocytes, with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CD3/anti-BCMA bispecific antibody TQB2934 binds to both
CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells.
This activates and redirects CTLs to BCMA-expressing tumor cells, which results in
the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the
tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant
plasma cells, plays a key role in promoting plasma cell survival.;
Semantic type(s)