Preferred Label : Anti-CLL1/Anti-CD33 CAR-T Cells LCAR-AMDR;
NCIt synonyms : CLL-1/CD33-targeted CAR T Cells LCAR-AMDR; Anti-CLL1/CD33 CAR T-cells LCAR-AMDR;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) C-type-lectin-like
molecule-1 (CLL-1; CLL1; C-type lectin domain family 12 member A; CLEC12A) and CD33,
with potential immunomodulating and antineoplastic activities. Upon administration,
the anti-CLL1/anti-CD33 CAR-T cells LCAR-AMDR specifically and simultaneously target
and bind to CD33- and CLL1-expressing tumor cells. This induces selective toxicity
in CD33- and CLL1-expressing tumor cells. CD33 is expressed on normal non-pluripotent
hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member
of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed
in leukemic stem cells (LSCs) and plays an important role in disease progression and
relapse for myeloid malignancies.;
Molecule name : LCAR-AMDR;
NCI Metathesaurus CUI : CL1906243;
Origin ID : C199306;
UMLS CUI : C5854670;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
