Preferred Label : Anti-B7-H3 Antibody-drug Conjugate MHB088C;
NCIt synonyms : Antibody-drug Conjugate MHB088C; Anti-B7-H3 ADC MHB088C;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) conjugated to an
as of yet undisclosed topoisomerase-1 inhibitor via a cleavable linker, with potential
antineoplastic activity. Upon administration of anti-B7-H3 ADC MHB088C, the antibody
moiety targets and binds to B7-H3-expressing tumor cells. Upon binding, internalization
and linker cleavage, the topoisomerase-1 inhibitor is released and inhibits DNA topoisomerase
I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest
and apoptosis in tumor cells expressing B7-H3. B7-H3, a type I transmembrane protein
and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain
tumor cell types and on various immune cells. It is a negative regulator of T-cell
activation, and its overexpression plays a key role in tumor cell invasion and metastasis.;
Molecule name : MHB-088C; MHB 088C;
NCI Metathesaurus CUI : CL1906225;
Origin ID : C199295;
concept_is_in_subset
- has_target
