Preferred Label : Anti-Factor Bb Monoclonal Antibody NM8074;
NCIt synonyms : Anti-Bb Monoclonal Antibody NM8074;
NCIt definition : A humanized monoclonal antibody directed against complement factor Bb (FBb; Bb) that
can be used to treat various alternate pathway (AP)-mediated diseases. Upon administration,
anti-factor Bb monoclonal antibody NM8074 selectively targets, binds to and neutralizes
Bb. This prevents the binding of Bb to C3 and prevents the formation of protease C3
convertase (C3Bb). This prevents the conversion of C3 into the fragments C3a and C3b,
thereby preventing C3b deposition and C3b-mediated extravascular hemolysis. Also,
by preventing the formation of C3Bb, C3Bb is unable to bind to C3b to form the protease
C5 convertase (C3BbC3b). As C5 convertase is responsible for the conversion of C5
to C5a/C5b and initiation of membrane attack complex (MAC), NM8074 is able to prevent
MAC-mediated tissue damage. Altogether, NM8074 inhibits the activation of the alternative
complement pathway (ACP). Overactivation of AP plays a key role in the initiation
and propagation of C3b deposition, inflammation and tissue destruction. Bb is created
when complement factor D, a serine protease, cleaves complement factor B into 2 fragments,
Ba and Bb, in the AP of the complement cascade. NM8074 does not block the classical
pathway (CP) which is critical for host defense against infections.;
Molecule name : NM 8074; NM-8074;
NCI Metathesaurus CUI : CL1906226;
Origin ID : C199294;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
