Preferred Label : Fluorine F 18 FAPI-74;
NCIt synonyms : [18F]FAPI-74; 18F-FAPI-74;
NCIt definition : A radioconjugate composed of FAPI-74, a quinoline-based fibroblast activation protein
(FAP)-targeted tracer belonging to the group of FAP inhibitors (FAPi) conjugated to
the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA) and labeled with the positron-emitting radioisotope fluorine F 18, with
potential use as a tracer for FAP-expressing tumors and cancer-associated fibroblasts
(CAFs) during positron emission tomography (PET). Upon administration of fluorine
F 18 FAPI-74, the FAPI-74 moiety targets and binds to FAP-expressing tumor cells and
FAP-expressing CAFs. Upon binding and internalization, FAP-expressing tumor cells
and CAFs can be detected during PET imaging. FAP, a cell surface protein, is overexpressed
in a variety of human cancer cell types and on CAFs in the tumor microenvironment
(TME).;
NCI Metathesaurus CUI : CL1906229;
Origin ID : C199291;
UMLS CUI : C5855519;
Semantic type(s)
- concept_is_in_subset
- has_target
