Preferred Label : Allogeneic Anti-CD19 T-cells ThisCART19A;
NCIt synonyms : Allogeneic CD19-specific CAR T-cells ThisCART19A; ThisCART19A; CD19-directed ThisCART Cells ThisCART19A;
NCIt definition : A preparation of allogeneic engineered T-lymphocytes expressing a lentiviral vector
encoding chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA)
CD19 and an anti-CD3 single chain antibody with the KDEL peptide fused to its C-terminus,
with potential immunostimulating and antineoplastic activities. Upon administration,
allogeneic anti-CD19 CAR T-cells ThisCART19A specifically target and bind to CD19-expressing
tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen
is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.
By eliminating TCR/CD3 expression, the potential induction of graft-versus-host disease
(GvHD) by the donor T-cells is abrogated.;
NCI Metathesaurus CUI : CL1906218;
Origin ID : C199286;
UMLS CUI : C5855517;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
