Preferred Label : Microbiome-derived Peptide Vaccine EO2040;
NCIt synonyms : Cancer Vaccine EO2040; Microbial-derived Peptide Vaccine EO2040; Microbial-derived Peptide Therapeutic Vaccine EO2040;
NCIt related terms : icrobiome-derived Peptide Vaccine EO2040;
NCIt definition : An off-the-shelf (OTS), microbiome therapeutic cancer peptide vaccine composed of
two onco-mimics, which are immunogenic microbiomal-derived peptides that are highly
homologous to specific tumor-associated antigens (TAAs) and are obtained and selected
from the human gut microbiome, combined with the helper peptide and CD4-positive T-cell
epitope universal cancer peptide 2 (UCP2), and emulsified with the immunoadjuvant
Montanide, with potential immunomodulating and antineoplastic activities. Upon administration
of microbiome-derived peptide vaccine EO2040, the peptides are taken up by and presented
on dendritic cells (DCs) to T-cells. As the presented antigens display molecular mimicry
with selected TAAs on colorectal cancer cells, a cytotoxic T-lymphocyte (CTL)-mediated
immune response may be mounted against the cancer cells expressing the TAAs, thereby
eradicating the cancer cells. UCP2 is able to activate the immune system to mount
a T-helper 1 (TH1) CD4-positive T-lymphocyte immune response thereby further killing
tumor cells.;
Molecule name : EO-2040; EO 2040;
NCI Metathesaurus CUI : CL1906188;
Origin ID : C199254;
chemical_or_drug_has_mechanism_of_action
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