TCF4/HLF Fusion Gene

Preferred Label : TCF4/HLF Fusion Gene;

NCIt synonyms : TCF4-HLF Fusion Gene; TCF4::HLF Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal rearrangement with breakpoints in the vicinity of 18q21.2 and 17q22 that fuses exon 15 of the TCF4 gene upstream of exon 3 of the HLF gene. This rare rearrangement is associated with childhood pre-B cell acute lymphoblastic leukemia.;

NCI Metathesaurus CUI : CL1906180;

PubMed : 30487223;

Details

Origin ID

C199246;

gene_encodes_gene_product
- TCF4/HLF Fusion Protein [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- B Acute Lymphoblastic Leukemia with TCF4-HLF Rearrangement [NCIt concept]
gene_mapped_to_disease
- B Acute Lymphoblastic Leukemia with TCF4-HLF Rearrangement [NCIt concept]
gene_plays_role_in_process
- Transcriptional Activation [NCIt concept]
related_to_genetic_biomarker
- HLF Gene [NCIt concept]
- TCF4 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients