B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, JAK-STAT Activated

Preferred Label : B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, JAK-STAT Activated;

NCIt synonyms : B-Acute Lymphoblastic Leukemia, BCR::ABL1-Like, JAK-STAT Activated; B Acute Lymphoblastic Leukemia, BCR::ABL1-Like, JAK-STAT Activated; B-Acute Lymphoblastic Leukemia, BCR-ABL1-Like, JAK-STAT Activated; B-ALL, BCR::ABL1-Like, JAK-STAT Activated; B-ALL, BCR-ABL1-Like, JAK-STAT Activated;

NCIt definition : B-acute lymphoblastic leukemia, BCR-ABL1-like associated with aberrant activation of the JAK-STAT signaling pathway.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1906167;

Details

Origin ID

C199224;

Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Mature B-Lymphocyte [NCIt concept]
- Myeloid Cell [NCIt concept]
Disease may have findings
- Bone Pain [NCIt concept]
- Extensive Bone Marrow and Blood Involvement [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hepatomegaly [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Splenomegaly [NCIt concept]
- Thrombocytopenia [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphoblast [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphoblast [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Activating JAK-STAT Pathway Positive Ph-Like B Acute Lymphoblastic Leukemia [NCIt concept]
- BCR/ABL1 Fusion Negative [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Philadelphia Chromosome Negative [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
- Translocations Involving Tyrosine Kinases or Cytokine Receptors Present [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- JAK-STAT Pathway Deregulation [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphoblast [NCIt concept]
- Lymphocyte [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]

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