Preferred Label : Elritercept;
NCIt synonyms : Activin Type 2A Receptor Fc Fusion Protein KER-050; Activin Type IIA Receptor Fc Fusion Protein KER-050;
NCIt definition : A recombinant fusion protein composed of a modified form of the ligand-binding domain
of the human transforming growth factor beta (TGF-b) receptor activin receptor type
IIA (ActRIIA) and linked to the Fc domain of human antibody, with red blood cell (RBC)
and platelet stimulating activities. Upon subcutaneous administration, elritercept
acts as a ligand trap, and binds to a subset of the TGF-b family of proteins. This
inhibits the binding of these proteins to their receptors and blocks signaling mediated
by this subset of TGF-b family of proteins and their receptors. This may promote hematopoiesis
and increase RBC and platelet production.;
UNII : ZNC37E4KAK;
CAS number : 2727114-26-1;
Molecule name : KER 050; KER-050;
NCI Metathesaurus CUI : CL1906148;
Origin ID : C199201;
UMLS CUI : C5855452;
Semantic type(s)
concept_is_in_subset