Preferred Label : Zavondemstat;
NCIt synonyms : Histone Lysine Demethylase 4 Inhibitor TACH101; KDM4 Inhibitor TACH101;
NCIt definition : An orally bioavailable, small-molecule, pan inhibitor of histone lysine (K) demethylase
4 (KDM4), with potential antineoplastic activity. Upon oral administration, zavondemstat
specifically targets, binds to and inhibits the catalytic activity of all members
of the KDM4 family of proteins. This may prevent KDM4-mediated signaling, epigenetic
dysregulation and inhibit the proliferation of tumor cells. The KDM4 family of histone
demethylases is frequently upregulated in a variety of cancers and plays an important
role in nuclear functions including the regulation of transcription, cell cycle, and
DNA replication and repair.;
UNII : 4L3YJL2P4P;
CAS number : 1851412-93-5;
Molecule name : QC 8222; TACH-101; TACH 101; QC-8222;
NCI Metathesaurus CUI : CL1906087;
Origin ID : C199135;
UMLS CUI : C5855397;
Semantic type(s)
- concept_is_in_subset
