Preferred Label : Imsapepimut;
NCIt synonyms : IDO Peptide Vaccine IO102; Imsamotide; IDO-derived Vaccine IO102; Indoleamine 2,3-dioxygenase-derived Peptide Vaccine; IO-102;
NCIt definition : A second-generation peptide vaccine derived from the immunomodulatory enzyme indoleamine
2,3-dioxygenase (IDO) with potential immunomodulating and antineoplastic activities.
Vaccination with imsapepimut may activate the immune system to induce an immune response
against IDO-expressing tumor cells. This may restore the proliferation and activation
of various immune cells including cytotoxic T-lymphocytes (CTLs), natural killer cells
(NKs), and dendritic cells (DCs), and may eradicate IDO-expressing tumor cells through
a CTL-mediated response. IDO, a cytosolic enzyme responsible for tryptophan catabolism
and conversion of tryptophan into kynurenine, is overexpressed by a variety of tumor
cell types and antigen presenting cells (APCs) and plays an important role in immunosuppression
mainly through suppression of CTL activation.;
UNII : V74I849BP9;
CAS number : 2130836-27-8;
Molecule name : IO102; IO 102;
NCI Metathesaurus CUI : CL1906482;
Origin ID : C199060;
UMLS CUI : C5855337;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
