Preferred Label : Lenalidomide Prolonged-release Formulation NEX-20A;
NCIt synonyms : Lenalidomide Long-acting Formulation NEX-20A;
NCIt definition : A prolonged-release formulation composed of a suspension of the thalidomide analog
lenalidomide coated with slow-dissolving nontoxic inorganic oxides, with potential
antineoplastic activity. Upon administration via subcutaneous injection, the coating
dissolves and lenalidomide is released. Lenalidomide inhibits tumor necrosis factor
alpha (TNF-alpha) production, stimulates T-lymphocytes, reduces serum levels of vascular
endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF; FGF2),
and inhibits angiogenesis. Additionally, lenalidomide promotes G1 cell cycle arrest
and induces apoptosis in malignant cells.;
Molecule name : NEX-20A; NEX 20A;
NCI Metathesaurus CUI : CL1906417;
Origin ID : C198985;
chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
