Preferred Label : Long-acting Recombinant Erwinia asparaginase JZP-341;
NCIt synonyms : Long-acting Recombinant Erwinia asparaginase PF745;
NCIt definition : A long-acting and recombinant form of asparaginase (Erwinia asparaginase; crisantaspase),
with potential antineoplastic activity. Upon administration of long-acting recombinant
Erwinia asparaginase JZP-341, the recombinant asparaginase hydrolyzes L-asparagine
to L-aspartic acid and ammonia. This depletes cancer cells of asparagine, which blocks
protein synthesis and tumor cell proliferation. Asparagine is critical to protein
synthesis in cancer cells, which cannot synthesize this amino acid due to the absence
of the enzyme asparagine synthase.;
Molecule name : JZP 341; PF 745; PF-745; JZP-341;
NCI Metathesaurus CUI : CL1906405;
Origin ID : C198981;
UMLS CUI : C5854383;
Semantic type(s)
- concept_is_in_subset
