Preferred Label : Carbon C 13 Hyperpolarized Bicarbonate;
NCIt synonyms : HP 13C-labeled Bicarbonate; Hyperpolarized 13C-bicarbonate; Hyperpolarized 13C Bicarbonate; 13C HP Bicarbonate;
NCIt definition : A hyperpolarized (HP) bicarbonate labeled with carbon C 13 (13C), with potential usage
in the diagnostic nuclear magnetic resonance (NMR) imaging of cancer cells. Upon administration,
carbon C 13 hyperpolarized bicarbonate can be used for the in vivo pH mapping of tumors.
As tumor microenvironment (TME) are often acidic, the acidic extracellular pH can
be detected and visualized upon NMR using 13C HP bicarbonate. Hyperpolarization of
13C-bicarbonate enhances NMR signals. The acidity of the TME is correlated in tumor
aggressiveness, metastatic potential, and therapeutic response.;
NCI Metathesaurus CUI : CL1906383;
Origin ID : C198956;
UMLS CUI : C5855259;
Semantic type(s)
- concept_is_in_subset
