NCIt definition : A messenger RNA (mRNA) vaccine consisting of six mRNAs five of which encode the human
cytomegalovirus (CMV) subunits that form the membrane-bound pentamer protein complex
and one that encodes the full-length membrane-bound glycoprotein B (gB), with potential
immunostimulatory activity against CMV. Upon intramuscular (IM) administration of
the CMV pentamer complex proteins/gB-encoding mRNA vaccine mRNA-1647, the mRNAs are
translated by the cellular protein translation machinery to produce the proteins.
This exposes the immune system to the six peptides, activates both humoral and cellular
immune responses, and may provide active immunization against both the pentamer proteins
and gB and therefore against CMV infection. Both the pentamer, consisting of gH, gL,
UL128, UL130 and UL131 proteins, and gB are essential for CMV to infect barrier epithelial
surfaces. CMV can cause significant disease in immunocompromised patients.;
Semantic type(s)