Preferred Label : International Neuroblastoma Response Criteria, Brodeur 1993;
NCIt synonyms : INRC, Brodeur 1993;
NCIt related terms : INRC 1993; International Neuroblastoma Response Criteria 1993;
NCIt definition : A revision of the International Neuroblastoma Staging System (INSS) and International
Neuroblastoma Response Criteria (INRC). The revisions included redefinition of the
midline, restrictions on age and bone marrow involvement for stage 4S, and the recommendation
that meta-iodobenzylguanidine (MIBG) scanning be implemented for evaluating the extent
of disease. The biologic features that were deemed important to evaluate included
serum ferritin, neuron-specific enolase (NSE), and lactic dehydrogenase (LDH); tumor
histology; tumor-cell DNA content; assessment of N-Myc copy number; assessment of
chromosome 1p deletion by cytogenetic or molecular methods; and high affinity nerve
growth factor receptor (Trk-A) expression.;
Alternative definition : CDISC: Revisions of the international criteria for neuroblastoma diagnosis, staging,
and response to treatment. (Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel
V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F, et al. Revisions
of the international criteria for neuroblastoma diagnosis, staging, and response to
treatment. J Clin Oncol. 1993 Aug;11(8):1466-77.);
NCI Metathesaurus CUI : CL1906310;
Origin ID : C198865;
UMLS CUI : C5855186;
Semantic type(s)
- concept_is_in_subset
