Preferred Label : Oxidative DNA Damage;
NCIt synonyms : Oxidative Damage of DNA; DNA Oxidation;
NCIt definition : The oxidation of deoxyribonucleosides in DNA strands, which may occur due to exposure
to reactive oxygen species (ROS). Under normal conditions, low levels of oxidized
nucleosides are present; this steady state level may play a role epigenetic control
of gene expression and is maintained by enzymes of the base excision repair (BER)
pathway. Elevated levels of oxidative DNA damage are associated with oxidative stress,
tumorigenesis and certain diseases, including neurologic conditions such as Alzheimer
disease, systemic lupus erythematosus, bipolar disorder and schizophrenia.;
NCI Metathesaurus CUI : CL1638207;
Origin ID : C198713;
biological_process_has_associated_location
- biological_process_has_result_biological_process
- concept_is_in_subset
