Preferred Label : Allogeneic Gamma Delta T-cells GDKM-100;
NCIt synonyms : Allogeneic Gamma-delta T Cells GDKM-100;
NCIt definition : A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain
and delta chain T-cell receptors (TCRs), with potential immunomodulating and antineoplastic
activities. Upon administration of the allogeneic gamma delta T-cells GDKM-100, these
cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In
addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte
(CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the
activation of the immune system and do not require major histocompatibility complex
(MHC)-mediated antigen presentation to exert their cytotoxic effect.;
Molecule name : GDKM 100; GDKM-100;
NCI Metathesaurus CUI : CL1913985;
Origin ID : C198221;
UMLS CUI : C5786913;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
