Preferred Label : Actinium Ac 225 FPI-2059;
NCIt synonyms : Ac 225 FPI-2059; [225Ac]-FPI-2059; 225Ac-FPI-2059;
NCIt definition : A radioconjugate consisting of a neurotensin receptor type 1 (NTSR1)-targeting small
molecule antagonist labeled with the alpha-emitting radioisotope actinium Ac 225,
with potential antineoplastic activity. Upon administration of actinium Ac 225 FPI-2059,
the NTSR1-targeting moiety targets and binds to NTSR1 expressed on tumor cells. Upon
binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to NTSR1-expressing
tumor cells. NTSR1, a G protein-coupled receptor for the tridecapeptide neurotensin
(NTS), is overexpressed in certain types of cancers and plays a key role in tumor
cell proliferation.;
NCI Metathesaurus CUI : CL1913986;
Origin ID : C198218;
UMLS CUI : C5786910;
Semantic type(s)
- concept_is_in_subset
- has_target
