NCIt definition : Human DRD2 Gene at 11q23 encodes Dopamine Receptor D2, a G-protein coupled receptor
that inhibits adenylyl cyclase activity. Missense mutation in DRD2 causes myoclonus
dystonia; other mutations have been associated with schizophrenia. Alternative splicing
results in two different isoforms. A third variant has been described, but it has
not been determined whether this form is normal or due to aberrant splicing. Different
alleles are associated with increased incidence of substance abuse. (NCI);