Preferred Label : Autologous GM-CSF-secreting Lethally Irradiated Lung Cancer Vaccine;
NCIt synonyms : GVAX Autologous Lung Cancer Vaccine; GVAX Lung Cancer Vaccine; Autologous GVAX Lung Cancer Vaccine;
NCIt definition : An autologous lung cancer vaccine consisting of patient-specific lung cancer cells
genetically modified to secrete granulocyte-macrophage colony stimulating factor (GM-CSF),
an immunostimulatory cytokine. GM-CSF modulates the proliferation and differentiation
of a variety of hematopoietic progenitor cells with some specificity towards stimulation
of leukocyte production and may reverse treatment-induced neutropenias. This agent
also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity
(ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function
and may augment host antitumoral immunity. For safety, cells are irradiated prior
to vaccination. (NCI04);
Molecule name : CG8123;
NSC code : 730428;
Origin ID : C1979;
UMLS CUI : C1328108;
Semantic type(s)
- concept_is_in_subset
