Preferred Label : Depsipeptide Antineoplastic Antibiotic;
NCIt synonyms : Depsipeptide; Depsipeptide Antibiotic;
NCIt definition : A bicyclic peptide antibiotic with one or more amide bonds replaced by ester bonds.
Depsipeptide antibiotics act as histone deacetylase inhibitors and regulate chromatin
structure and transcription by increasing histone acetylation, thereby resulting in
alterations in gene expression and inducing cell differentiation, cell cycle arrest,
and apoptosis.;
Origin ID : C1976;
UMLS CUI : C4082795;
Currated CISMeF NLP mapping
- Semantic type(s)
