Preferred Label : Oncolytic Influenza A Virus;
NCIt definition : An attenuated oncolytic influenza A virus, with hemagglutinin and neuraminidase genes
of influenza virus strain A/California/07/2009 codon-pair deoptimized, with potential
oncolytic activity. Upon intratumoral administration, oncolytic influenza A virus
selectively targets and replicates in cancer cells without being able to infect and
replicate in normal, healthy cells. This induces selective oncolytic virus-mediated
cytotoxicity in cancer cells, which leads to cancer cell lysis. Following the lysis
of infected cells, the replicated virus is released and can infect adjacent tumor
cells, which both induces further tumor cell oncolysis and may activate the immune
system to exert an anti-tumor immune response against the tumor cells.;
Drug name : CodaLytic;
NCI Metathesaurus CUI : CL1913094;
Origin ID : C193472;
UMLS CUI : C5785781;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
