Preferred Label : EGFR Tri-specific Natural Killer Cell Engager DF9001;
NCIt synonyms : EGFR Tri-specific NK Cell Engager DF9001; EGFR-targeting Tri-specific NK Cell Engager DF9001; TriNKET DF9001;
NCIt definition : A tri-specific natural killer (NK) cell engager targeting epidermal growth factor
receptor (EGFR), with potential immunostimulating and antineoplastic activities. Upon
administration, EGFR tri-specific NK cell engager DF9001 targets and binds to EGFR
on tumor cells and simultaneously binds to NK cells, thereby bringing EGFR-expressing
tumor cells and NK cells together. This stimulates the NK cells and results in the
selective NK cell-mediated killing of EGFR-expressing tumor cells. In addition, the
NK cells activate T- and B-cells, and enhance a cytotoxic T-lymphocyte (CTL)-mediated
immune response against EGFR-expressing tumor cells. EGFR, overexpressed by a variety
of cancers, plays a key role in tumor cell proliferation and survival.;
Molecule name : DF 9001; DF-9001;
NCI Metathesaurus CUI : CL1913105;
Origin ID : C193460;
UMLS CUI : C5787285;
Semantic type(s)
- concept_is_in_subset
- has_target
