Preferred Label : Anti-LILRB Monoclonal Antibody ADA-011;
NCIt synonyms : Anti-leukocyte Immunoglobulin-like Receptors B Monoclonal Antibody ADA-011;
NCIt related terms : ADA-011;
NCIt definition : A monoclonal antibody targeting the leukocyte immunoglobulin-like receptors B (LILRB)
immune checkpoint receptor family, with potential immune checkpoint inhibitory, immunomodulating
and antineoplastic activities. Upon administration, anti-LILRB monoclonal antibody
ADA-011 targets, binds to and inhibits LILRB family members and their downstream signaling
pathways. This may restore immune function and anti-tumor immune responses. The LILRB
receptor family is a family of inhibitory immune checkpoint receptors that negatively
regulates immune activation and plays an important role in immune evasion. Various
LILRBs are expressed on certain types of cancer cells and play a key role in cancer
development.;
UNII : DFK2GHG34Y;
Molecule name : ADA-011; ADA 011;
NCI Metathesaurus CUI : CL1913097;
Origin ID : C193451;
UMLS CUI : C5785762;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
