" /> Adenosine Receptor - CISMeF





Preferred Label : Adenosine Receptor;

Obsolete resource : true;

NCIt definition : One of the purinergic P1 receptors that prefers adenosine to other endogenous purines.; The three conserved (GPCR Family) widely expressed types of Adenosine Receptors (A1, A2, A3) exhibit specific patterns of ligand binding and unique tissue distributions. Each cell-surface integral membrane protein receptor contains a 7 transmembrane domain and interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate or suppress cAMP accumulation through adenylate cyclase activation or inhibition. Regulating diverse physiologic functions (cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation), adenosine receptors modulate the activity of neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress.;

NCIt note : See 'Purinergic-P1 Receptor';

Concept status : Retired_Concept;

NCI Metathesaurus CUI : CL414397;

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30/07/2025


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