Preferred Label : Neoantigen Heat Shock Protein Vaccine rHSC-DIPGVax;
NCIt synonyms : Hsp Vaccine rHSC-DIPGVax; Neoantigen Hsp Vaccine rHSC-DIPGVax; rHSC-DIPGVax;
NCIt definition : An off-the-shelf (OTS) peptide-based cancer vaccine consisting of sixteen heat shock
protein (Hsp) neo-epitopes that are found in the majority of diffuse intrinsic pontine
glioma (DIPG) and diffuse midline glioma (DMG) tumors, with potential immunomodulating
and antineoplastic activities. Upon administration of the neoantigen Hsp vaccine rHSC-DIPGVax,
the peptides stimulate the host immune system to mount a specific cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing the Hsp neo-epitopes, which results
in tumor cell lysis. Hsps are overexpressed in a variety of tumor cell types.;
NCI Metathesaurus CUI : CL1912810;
Origin ID : C192844;
UMLS CUI : C5785462;
Semantic type(s)
- concept_is_in_subset
