Preferred Label : TLR7 Agonist CAN1012;
NCIt definition : A Toll-like receptor type 7 (TLR 7) agonist, with potential immunostimulating and
antineoplastic activities. Upon intratumoral (IT) administration, TLR7 agonist CAN1012
targets, binds to and activates TLR7, thereby activating TLR7-mediated pathways. This
stimulates the maturation and activation of antigen-presenting cells (APCs), including
dendritic cells (DCs). Activation of DCs results in the production of pro-inflammatory
cytokines, and the activation of cytotoxic T-lymphocyte (CTL)- and B-lymphocyte-mediated
immune responses. This may lead to tumor cell lysis. TLR7, a member of the TLR family,
plays a fundamental role in the activation of the innate immune system, myeloid cell
responses and tumor antigen presentation.;
Molecule name : CAN 1012; CAN-1012;
NCI Metathesaurus CUI : CL1912847;
Origin ID : C192814;
UMLS CUI : C5785437;
Semantic type(s)
- concept_is_in_subset
