Preferred Label : Microbiome-derived Peptide Vaccine EO4010;
NCIt synonyms : Cancer Vaccine EO4010; Microbial-derived Peptide Vaccine EO4010; Microbial-derived Peptide Therapeutic Vaccine EO4010;
NCIt definition : A microbiome therapeutic cancer peptide vaccine composed of onco-mimics, immunogenic
microbiome-derived peptides that are highly homologous to specific tumor-associated
antigens (TAAs), that are obtained and selected from the human gut microbiome, with
potential immunomodulating and antineoplastic activities. The five microbiome-derived
bacterial antigens in EO4010 mimic five TAAs that are highly expressed by colorectal
cancer cells. Upon administration of microbiome-derived peptide vaccine EO4010, the
peptides are taken up by and presented on dendritic cells (DCs) to T-cells. As the
presented antigens display molecular mimicry with selected TAAs on colorectal cancer
cells, a memory T-cell- and cytotoxic T-lymphocyte (CTL)-mediated immune response
may be mounted against the cancer cells expressing the TAAs, thereby eradicating the
cancer cells.;
Molecule name : EO-4010; EO 4010;
NCI Metathesaurus CUI : CL1912842;
Origin ID : C192811;
UMLS CUI : C5785434;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
