Ataxin-7 - CISMeF

Preferred Label : Ataxin-7;

NCIt synonyms : ATXN7; Ataxin 7; Spinocerebellar Ataxia Type 7 Protein;

NCIt definition : Ataxin-7 (892 aa, 95 kDa) is encoded by the human ATXN7 gene. This protein is involved in the regulation of histone acetylation and chromatin remodeling.;

NCIt note : Ataxin-7 is part of the STAGA (SPT3/TAF9/GCN5) transcriptional co-activator complex, which acetylates histone H3 and possibly H4, and the TBP-free TAF-containing (TFTC) histone acetylation complex, a chromatin-acetylating transcription coactivator with histone acetyltransferase activity. (UniProt and ComplexPortal);

NCI Metathesaurus CUI : CL1912916;

Details

Origin ID

C192714;

UMLS CUI

C1620219;

OMIM relation
- Ataxin 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ATXN7 protein, human [MeSH Supplementary Concept]
- ATXN7 protein, human [MeSH concept]
gene_encodes_gene_product
- ATXN7 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- Transcription Coactivator [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Deubiquitination [NCIt concept]
- Histone Acetylation [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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