Preferred Label : Universal Donor Expanded TGF-beta-imprinted NK Cells;
NCIt synonyms : Allogeneic TGFBi Expanded NK Cells; Universal Donor TGF-beta Imprinted Expanded NK Cells; UD TGF-betai NK Cells;
NCIt definition : A preparation of ex vivo expanded, universal donor, transforming growth factor-beta
(TGF-beta; TGF-b) imprinted natural killer (NK) cells, with potential cytolytic and
antineoplastic activities. Upon administration, the universal donor expanded TGF-beta-imprinted
NK cells may directly lyse cancer cells. These cells also secrete pro-inflammatory
cytokines and further stimulate a systemic immune response against cancer cells. TGF-beta
imprinting during NK cell activation and expansion decreases NK cell sensitivity to
TGF-beta suppression and promotes NK cell cytokine hypersecretion, specifically of
interferon-gamma (IFNg) and tumor necrosis factor-alpha (TNFa), and enhances NK cytotoxicity.
TGF-beta is a potent immunosuppressive cytokine that inhibits the anti-tumor responses
of NK cells and T-cells.;
NCI Metathesaurus CUI : CL1912917;
Origin ID : C192713;
UMLS CUI : C5785381;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
